Paracetamol and chlorzoxazone are well-known for their ability to treat rheumatoid arthritis and other joint pain problems. However, there is an issue with these medications' body absorption and bioavailability. This work focuses on the preparation and analysis of crystal co-agglomerates made with different polymer concentrations, such as PVA and HPMC K4M. The study's objective was to improve the drug's flow, wettability and dissolving properties as well as increase its body absorption for a more effective therapeutic effect. After the created co-agglomerates were assessed for various criteria, it was discovered that the F4 bath had the best flow ability, the highest drug content and the best dissolving properties. The created co-agglomerates were stable for the duration of the investigation without any appreciable changes to the preparation, according to the stability study and the SEM analysis, which both reveal the formation of distinct cylindrical crystals. It was determined that the process of creating crystal co-agglomerates was effective in enhancing the medication's stability and therapeutic response, as well as lowering the likelihood of the substance being metabolized.
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